Lea Rems

Lea Rems

KTH Royal Institute of Technology:
Postdoctoral Researcher

Plenary by Fabrizio Vincenti & Lea Rems

Theme: Can Membrane proteins act as biological probes for EM Fields?

Biography

Lea Rems is a postdoctoral researcher at KTH Royal Institute of Technology and Science for Life Laboratory in Stockholm, Sweden. She has a background in electrical engineering. Since her PhD she has been interested in understanding the basic mechanisms by which electric fields interact with biological cells and translating this knowledge into designing new or more efficient applications, specifically within the context of membrane electroporation. For this she has been using theoretical modeling on both the cellular level and the molecular level of the cell membrane. After finishing her PhD at the University of Ljubljana in Slovenia, supervised by Damijan Miklavčič and Mounir Tarek, she became a postdoc in the group of Pouyan Boukany at Delft University of Technology in the Netherlands. In 2018 she joined the groups of Lucie Delemotte and Ilaria Testa at KTH in Sweden. She is currently investigating ion channels, their involvement in electroporation as well as in neuronal plasticity, by combining modeling with insights from super-resolution microscopy.

List of selected publications:

  • Kotnik T, Rems L, Tarek M, Miklavčič D. 2019. Membrane Electroporation and Electropermeabilization: Mechanisms and Models, Annu. Rev. Biophys. Accepted for publication.
  • Rems L, Viano M, Kasimova MA, Miklavčič D, Tarek M. 2019. The contribution of lipid peroxidation to membrane permeability in electropermeabilization: A molecular dynamics study. Bioelectrochemistry. 125:46–57
  • Perrier DL, Rems L, Boukany PE. 2017. Lipid vesicles in pulsed electric fields: Fundamental principles of the membrane response and its biomedical applications. Adv. Colloid Interface Sci. 249:248–271
  • Rems L, Tarek M, Casciola M, Miklavčič D. 2016. Properties of lipid electropores II: Comparison of continuum-level modeling of pore conductance to molecular dynamics simulations. Bioelectrochemistry. 112:112–124
  • Rems L, Ušaj M, Kandušer M, Reberšek M, Miklavčič D, Pucihar G. 2013. Cell electrofusion using nanosecond electric pulses. Sci. Rep. 3:3382